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G119S substitution results in steric hindrance, which reduces substrate or inhibitor binding, whereas F290V and F331W both modify the stabilisation process [84]

Statements Author contributions BD wrote this review and MV and JP revised it

Formation of coordinate covalent bonds

Brazil nuts, sardines, and grass-fed beef are excellent sources

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New pharmacological treatments for obesity: incretin analogues, their mechanism of action, efficacy and safety Incretin analogues are very effective weight loss medications resulting in weight loss approaching that achieved with bariatric surgery